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Background
Type 2 diabetes is a growing clinical and
public health problem. The
complications of diabetes can be reduced or prevented
by improving
glucose control, lowering blood pressure and lipids,
smoking cessation,
and taking ACE inhibitors. An even more effective approach
to preventing
these problems would be to prevent diabetes from developing.
Study Objective
To investigate the effectiveness of ramipril
in preventing diabetes among
high-risk persons
Inclusion criteria
Individuals who were 55 years or older with no evidence
of left ventricular
dysfunction or heart failure and who had evidence of
vascular disease or
one other risk factor for cardiovascular disease
Patient Number
5720
Study drugs
- Ramipril vs. placebo
- Ramipril was initiated at a dose of 2.5 mg once
daily followed by 5 mg
once daily for three weeks followed by 10 mg
Study duration
4.5 years
Results
- Ramipril reduced the development
of diabetes by 34%
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