Title

An assessment of the efficacy of atorvastatin in treating patients with dyslipidemia to target LDL cholesterol goals:
The Atorvastatin Matrix Study .

Purpose

To investigate the ability of atorvastatin at various doses, to enable patients with, or at risk of CHD, to enable LDL-cholesterol target levels .

Design

Non-comparative multicenter study .

Patients

531 patients with either a fasting total cholesterol of > 200 mg/dl and fasting triglyceride level up to 400 mg/dl while on current medications, or when current medication was not well tolerated .

Follow-up

12 weeks

Treatment regimen

Atorvastatin 10, 20 or 80 mg daily. Dose was determined by assignment of risk, based on entry level cholesterol levels and the presence of other established CHD risk factors .

Results

• Atorvastatin was successful in achieving target LDL cholesterol levels in 86% of mild-risk patients, 88% of moderate-risk
patients and 52% of high-risk patients.
• Compliance with atorvastatin was 96% and treatment was well established.

Conclusion

The study demonstrates that atorvastatin is effective in achieving target lipid levels in a large proportion of patients and the dose required can be predicted by an assessment of the patient's risk profile.