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Title
Effect of pravastatin (10 mg/day) on progression of
coronary atherosclerosis in patients with serum cholesterol
levels from 160 to 220 mg/dl and angiographically documented
coronary artery disease .
Purpose
To evaluate the effect of pravastatin on progression
of coronary atherosclerosis in normocholesterolaemic
patients with coronary artery disease (CAD) .
Design
Randomized, placebo-controlled study .
Patients
90 patients with CAD and serum cholesterol levels of
160 to 220 mg/dl.
Follow-up
2 years
Treatment regimen
Pravastatin 10 mg/day (n=39) vs placebo (n=41) .
Results
• Percent changes in lipids were significantly
greater in the pravastatin group than in the control
group (total cholesterol
- 11±12% vs 3±15%; LDL -18±16%
vs 4±21%).
• The proportion of patients with progression of
coronary atherosclerosis was significantly smaller in
the pravastatin
group than in the control group (21% vs 49%).
• The proportion of patients with disease regression
did not differ in the two groups (3% vs 2%) .
Conclusion
Cholesterol lowering with pravastatin can prevent the
progression of coronary atherosclerosis even in normocholesterolaemic
patients with CAD.
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