CIPLADOC - Cardiology Update - Cardiology Publications - Hyperlipidaemia - Drug treatment for hyperlipidaemia

A Practical Guide To Management of Hyperlipidaemia

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Drug treatment for hyperlipidaemia

Available drug options

Class	Examples	Dose	Effects on lipids
Statins (HMG-CoA reductase inhibitors)	Simvastatin	5-80 mg	LDL by 20-60%
	Lovastatin	10-80 mg	HDL by 5-15%
	Atorvastatin	10-80 mg	Triglycerides by 10-45%
Fibrates	Gemfibrozil	1200 g	LDL by 10-15%
			HDL by 10-15%
			Triglycerides by 20-50%
—	Nicotinic acid	0.5-3 g	LDL by 10-25%
			HDL by 15-35%
			Triglycerides by 20-50%
			Lp(a) by 5-30%
Resins (Bile acid sequestrants)	Cholestyramine	4-24 g	LDL by 15-30%
	Colestipol	5-30 g	HDL by 3-5%
			No effect or Triglycerides

Every 1% decrease in cholesterol decreases CHD risk by 2.5%

Hypolipidaemic therapy: Side effects and contraindications

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