Fluconazole
Indications
Forcan is indicated for oropharyngeal, oesophageal,
vaginal candidiasis, systemic candidiasis, cryptococcal
meningitis, primary as well as maintenace therapy. Prevention
of fungal infection in patients with malignancy, AIDS,
in intensive care units and patients on immunosuppressive
drugs.
Dosage and Administration
ADULTS
Oropharyngeal candidiasis
200 mg in the first day followed by 100 mg once daily
for 7-14 days.
Oesophageal candidiasis
200 mg on the first day, followed by 100 mg once daily
for 21 days.
Vaginal candidiasis
150 mg single dose
Systemic candidiasis
400 mg on first day, then 200 mg once daily. i/v may be
preferred.
Cryptococcal meningitis (in HIV patients)
400 mg orally for 8 weeks following a regimen of Amphotericin
B, 0.7 mg/kg i.v. daily + Flucytosine 25 mg/kg q.i.d.
for 2 weeks.
Maintenance to prevent relapse of cryptococcal meningitis
200 mg daily
Prophylaxis in immunocompromised
50-400 mg once daily started several days before onset
of neutropenia and continued for 7 days after neutrophil
count > 1000 cells/mm³.
CHILDREN
Mucosal candidiasis
< 2 weeks: 3 mg/kg every 72 hrs
2-4 weeks: 3 mg/kg every 48 hrs
over 4 weeks: 3 mg/kg daily
Systemic candidiasis
< 2 weeks: 6-12 mg/kg every 72 hrs
2-4 weeks: 6-12 mg/kg every 48 hrs
over 4 weeks: 6-12 mg/kg daily
Prophylaxis in immunocompromised
< 2 weeks: 3-12 mg/kg every 72 hrs
2-4 weeks: 3-12 mg/kg every 48 hrs
over 4 weeks: 3-12 mg/kg daily
Side effects
Nausea, vomiting, abdominal pain, headache, skin rash
and diarrhoea. Mild transient, reversible increase in
liver enzymes like ALT, AST, alkaline phosphatase and
serum bilirubin, etc may be seen.
Presentation
Forcan-50 Strip of 4 capsules
Forcan-150 Strip of 1 capsule
Forcan-200 Strip of 4 capsules
Forcan I.V. Injection Bottle of 100 ml
Forcan 100 DT Blister of 4 tablets |
