Composition
Cefoprox-100
Tablets
Each film coated tablet contains ....
Cefpodoxime Proxetil equivalent to Cefpodoxime 100
mg
Cefoprox-200
Tablets
Each film-coated tablet contains ....
Cefpodoxime Proxetil equivalent to Cefpodoxime 200
mg
Cefoprox-50
Dry Syrup
Each 5 ml of reconstituted suspension contains Cefpodoxime
Proxetil equivalent to Cefpodoxime 50 mg
Cefoprox-100
Dry Syrup
Each 5 ml of reconstituted suspension contains Cefpodoxime
Proxetil equivalent to Cefpodoxime 100 mg
Description
Cefpodoxime proxetil is an
extended spectrum third generation oral cephalosporin,
a prodrug of cefpodoxime. The antibacterial action
of cefpodoxime is through inhibition of bacterial
cell wall synthesis.
Cefpodoxime proxetil is active against gram positive
and gram negative bacteria. It is highly stable in
presence of beta-lactamase enzymes.
Indications
Cefoprox is indicated for the
treatment of the following infections:
Dosage
and Administration
Adults (Age 13 years
and older)
Upper respiratory tract infections,
100 mg 12 hourly for 5-10 days
Acute exacerbations of chronic bronchitis
200 mg 12 hourly for 10 days
Acute community-acquired pneumonia
200 mg 12 hourly for 14 days
Uncomplicated gonorrhoea
200 mg single dose
Uncomplicated urinary tract infections
100 mg 12 hourly for 7 days
Skin and skin structure infections
400 mg 12 hourly for 7 to 14 days
Children (Age 5 months through 12 years)
Acute otitis media
10 mg/kg (max 400 mg/dose) once daily or 5 mg/kg (max
200 mg/dose) 12 hourly for 10 days.
Pharyngitis and/or tonsillitis
5 mg/kg/dose (max 100 mg/dose) 12 hourly for 5-10 days.
HEPATIC INSUFFICIENCY
No dosage adjustment is recommended
for patients with hepatic insufficiency.
RENAL INSUFFICIENCY
Dosage of cefpodoxime should be modified according to
the degree of renal impairment for patients with creatinine
clearance of less than 30 ml/minute.
Contraindications
Cefoprox is contraindicated in
individuals who show hypersensitivity to cefpodoxime
proxetil, to cephalosportins or other beta-lactamas.
PREGNANCY
Cefpodoxime may be administered
to pregnant women only if clearly indicated.
LACTATION
Cefpodoxime is excreted in human
milk. A decision should be made whether to discontinue
nursing or to discontinue the drug.
ELDERLY
No dose adjustment is recommended
in elderly patients with normal renal function.
PAEDIATRIC USE
Cefpodoxime proxetil is not recommended
for infants under five months of age.
Side
Effects
Adverse effects reported in clinical
trials are mild and transient and include diarrhoea,
nausea, vomiting, abdominal pain, colitis and headache.
Rarely hypersensitivity reactions, rash, pruritus, dizziness,
thrombocytopenia, leucopenia or eosinophilia may occur.
Presentation
Cefoprox-100 Strip of
6 tablets
Cefoprox-200 Strip of 6 tablets
Cefoprox-50 Dry Syrup Bottle of 30 ml
Cefoprox-100 Dry Syrup Bottle of 30 ml
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