Description
Norfloxacin is a synthetic
broad spectrum antibacterial agent belonging to the
fluoroquinolone group. It exerts its bactericidal
effect by inhibiting the Asubunit of DNA gyrase, an
essential enzyme involved in DNA replication. Tinidazole
is a nitroimidazole which has antimicrobial action
against microaerophilic protozoa Giardia lamblia,
Entamoeba histolytica and Trichomonas vaginalis and
against obligate anaerobic bacteria. It acts by damage
of DNA strands or inhibition of their synthesis.
.
Indications
Treatment of diarrhoea and
dysentery of amoebic, bacterial or mixed origins.
Dosage
and Administration
The dosage is one tablet twice
daily for 5 days.
IMPAIRED
RENAL FUNCTION
If creatinine clearance is between
10 and 30 ml/minute the dose should be reduced to one
tablet daily.
Contraindications
Hypersensitivity to quinolone
group of compounds or nitroimidazoles.
Warnings and Precautions
DRUG INTERACTIONS
Alcohol: Metronidazole is reported
to have a disulfiramlike interaction with alcohol causing
nausea, vomiting, abdominal cramps and flushing. Patients
taking tinidazole should, therefore, avoid alcohol.
Probenecid: When coadministered with norfloxacin, probenecid
diminishes the urinary excretion of norfloxacin.
Nitrofurantoin: Nitrofurantoin antagonizes the antibacterial
effect of norfloxacin.
Theophylline: Plasma levels of theophylline have been
reported to be elevated when norfloxacin is given concurrently.
Oral anticoagulants: Norfloxacin, like other quinolones
may increase effects of oral anticoagulants.
Multivitamins: Multivitamins and preparations containing
iron or zinc, antacids or sucralfate should not be taken
concomitantly or within two hours after norfloxacin.
PREGNANCY
The drug should be avoided in
pregnancy.
NURSING MOTHERS
Norflox-TZ is not recommended
for use by nursing mothers.
PAEDIATRIC
USE
Fluoroquinolones have been shown
to cause degenerative changes (arthropathy) in weight
bearing joints of young animals. Norflox-TZ is not indicated
for use in children.
Side
Effects
Norfloxacin: Some cases of nausea,
headache, dizziness, fatigue, rash, abdominal pain,
dyspepsia, somnolence, depression, insomnia, constipation,
flatulence and heartburn have been reported. Less frequent
reactions include dry mouth, diarrhoea, fever, vomiting
and erythema.
Tinidazole: Metallic taste, nausea, vomiting, headache,
urticaria, hypersensitivity and early leucopenia
.
Presentation
Norflox-TZ Blister pack
of 6 tablets
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