Novaclox-LB - 250
Novaclox-LB - 500

Composition
Each capsule contains ....
Amoxycillin Trihydrate IP equivalent to Amoxycillin 250 mg and
Cloxacillin Sodium IP equivalent to Cloxacillin 250 mg and
Lactic acid bacillus 60 million spores.

Description
Novaclox-LB is a combination of two beta-lactam antibiotics, amoxycillin and cloxacillin combined with lactic acid. The antibiotics exert their bactericidal action by inhibition of cell wall synthesis.
Amoxycillin is active against a wide range of gram-positive and gram-negative pathogens, and cloxacillin acts against penicillinase producing gram-positive pathogens.
Lactobacillus is an aerobic gram-positive, ubiquitous inhabitant of the human oral cavity, vagina and gastrointestinal tract. It inhibits the colonization of pathogenic bacteria upon the intestinal epithelium by competitive exclusion.
Indications

RESPIRATORY TRACT INFECTIONS
Tonsillar abscess, otitis media, suppurative sinus infection, acute chronic bronchitis, bronchiectasis, bronchopneumonia, pleurisy, empyema, lung abscess, emphysema, bronchiolitis.

URINARY TRACT INFECTIONS
Acute and chronic pyelonephritis, cystitis, urethritis.

SKIN AND SOFT TISSUE INFECTIONS
Recurrent boils, carbuncles, impetigo, cellulitis and other infected dermatoses.

BONE INFECTIONS
Osteomyelitis and septic arthritis

SERIOUS INFECTIONS
Septicaemia, bacterial endocarditis, brain abscess and bacterial meningitis.
Dosage and Administration
Novaclox-LB
The dosage differs depending on the type, site and severity of infections. It is usually given as one capsule three to four times daily.

IN IMPAIRED RENAL FUNCTION
The dosage should be modified in patients with severe renal impairment, by increasing the intervals between doses. With a creatinine clearance between 10 and 50 ml/min the dosing interval can be up to 12 hours. If the clearance is less than 10 ml/min the interval can be 16 hours.

Contraindications
History of allergic reaction to any of the penicillins.

Warnings and Precautions
DRUG INTERACTIONS
Allopurinol: A significant increase in skin rashes is observed when allopurinol and amoxycillin are given concurrently.
Bacteriostatic drugs: such as chloramphenicol, erythromycin and tetracyclines may reduce the bactericidal action of amoxycillin and cloxacillin.

PREGNANCY
Novaclox-LB can be given during pregnancy. However the drug should be used with caution.

NURSING MOTHERS
Although the drug can be safely given to nursing mothers, there is some risk to the baby of sensitisation, skin rash and diarrhoea.

PAEDIATRIC USE
Because of incompletely developed renal function in new-borns, penicillinase-resistant penicillins may not be completely excreted, with abnormally high blood levels resulting. Frequent blood levels are advisable in this group.

Side Effects
As with all penicillins, side effects are generally those related to allergic response. Skin reactions ranging from pruritus, urticaria, and rashes are the most common allergic reactions. Hypersenitivity reactions may occur as bronchial asthma, urticaria and haemolytic anaemia.

Presentation
Novaclox-LB Strip of 6 capsules