Each pack contains 21 pills.

Composition
Drospirenone…….. 3mg
Ethinyl estradiol……..0.03mg

Indication: For Contraception

Mode of Action:

Janya acts :

• Primarily by inhibiting ovulation.
• Secondary mechanisms include thickening of the cervical mucus, changing endometrium, and reducing sperm transport.

JANYA a Novel Oral Contraceptive (OC) Pill:-

• JANYA is over 99.4 % effective in controlling pregnancy.
• JANYA a pill with Drospirenone unique progesterone with anti-mineralocorticoid and anti-androgenic properties.

Advantages of anti- mineralocorticoid properties:-  

• No weight gain
• No pill induced hypertension
• No Bloating

 Advantages of anti-androgenic properties:-  

• Reduction in acne
• Reduction in hirsutism
• Reduction in seborrhea

• Devoid of androgenic side – effects like acne, Hirsutism, Thinning of hair as with conventional OC pills.

Other benefits of JANYA use:  

• Reduced pain during menstruation
  Most women find periods become less painful and more manageable.
• Reduced blood loss during menstruation
  If females suffer from heavy periods, JANYA can also help by making them much lighter and easier to cope with and prevent problems associated with heavy blood loss (For example, iron deficiency).
• More regular cycle
  JANYA regulates menstrual cycle .
• Reduced PMS symptoms
  Many women find that especially JANYA significantly reduces symptoms associated with pre-menstrual syndrome like bloating, water retention, tender breasts and stomach cramps.

 Highlights:  

• Over 99% effective at preventing pregnancy.
• Janya does not have androgenic side effects of conventional contraceptive pill.
• Reduces Acne , seborrhea
• Reduces blood pressure.
• No pill induced hypertension.
• No weight gain
• No bloating
• Improves general well-being
• Better patient compliance
• Low discontinuation rate

Dose:
One pill per day for 21 day followed by 7 pill free days.

Watch Testospray Animation

First time in India Cipla Protec Launches- World's First Testosterone Hormone in Spray Form

Preface:

• 100 million men are ageing in India
• 20% of men over age of 60 experience hypogonadism and its symptoms due to decline in testosterone.

• Only 1 in 20 men with low Testosterone receive treatment.
• Testosterone deficiency affects libido.
• Testosterone deficiency affects structural and metabolic function at the level of trabeculae causing venous leakage and erectile dysfunction.

Composition : Testosterone 12.5mg per actuation

 Highlights of Testosterone Therapy:

• Increases libido, mood, cognition and lean muscle mass.
• Increases NO level causing smooth muscle dilatation.
• Improves response in erectile dysfunction if given in combination with PDE -5 inhibitors.

Highlights of Testospray:

• Convenience of use.
• Steady testosterone levels within the blood that minimizes potentially toxic peaks or ineffective troughs.
• Reduction in the frequency of drug administration resulting from the slow release of the drug into the blood stream.
• Minimal risk of transference to partners and children

Indications

• Adjunctive therapy with PDE –5 inhibitors in ED
• Erectile dysfunction with hypogonadism
• Men with primary hypogonadism (Hypergonadotrophic hypogonadism)
• Men with secondary Hypogonadism (Hypogonadotrophic hypogonadism)
• Men with late – onset hypogonadism (Andropause)
• Male infertility with Hypogonadism.

Dosage and administration:-

 Starting dose –
4 sprays (50 mg) per day once a day preferably every morning
14 days after initiation of therapy if clinical response is not achieved then dose may be increased to 8 sprays per day.

Site of application – Clean, dry, intact skin of the shoulder, abdomen or upper arms.

Do's and Don'ts:

 Do's:

• To be applied at the same time of day
• Application sites should be allowed to dry for 2 minutes prior to dressing.
• Hands should be washed thoroughly with soap and water after TESTO SPRAY has been sprayed.
• If direct skin-to–skin contact with other person is anticipated, the application sites must be washed thoroughly with soap and water.
• Testospray should be kept away from reach of children.

Dont's:

• Testospray should never be applied to the genitals (penis or scrotum) or to skin with wounds or irritation.
• Never keep TESTOSPRAY near flame.

Clearly Makes ERT Easy

First time in India Cipla Protec Launches
Estradiol hormone in transdermal spray form

• A total of 130 million Indian women are expected to live beyond the menopause into old age by 2015
  HRT has become an acceptable form of therapy. HRT , in particular estrogen therapy improves the quality of life.
• Estrogen therapy in India is still in its primitive stage of development with oral , injectable and gel form
• Transdermal Estrogen therapy appears to be more effective in symptom control (Vasomotor) as well as safe and well tolerated with less side effects.
• Estrogen in transdermal form can be used in IVF for “Priming of uterus” before embryo transfer.

Composition
Estradiol – 0.375mg (Per actuation)

Highlights
Easy

• Easy to use
• Less chances of transference to partner

Safe

• Transdermal estrogen is not associated with Venousthromboembolism. .
• No effect on tissue factor pathway inhibitors.

Effective

• 78% reduction in vasomotor symptoms
• Reduces chances of osteoporosis
• Reduces urogenital symptoms associated with menopause.

Indications

For ERT in menopausal female
For Priming of Uterus in IVF

Dosage and Administration

• Starting dose :-
• 2 sprays delivering 0.75 mg estradiol transdermal on clean, dry and intact skin of upper arm, shoulder and abdomen.
• According to clinical response dose can be increased upto 4 spray per day.
• Spray is to be applied at the same time of day preferably early morning.

Do's and Don'ts:

Do's:

• To be applied at the same time of day preferably every morning.
• Application sites should be allowed to dry for a few minutes prior to dressing.
• Hands should be washed thoroughly with soap and water after ESTASPRAY has been sprayed.
• If direct skin-to–skin contact with other person is anticipated, the application sites must be washed thoroughly with soap and water.

 Don'ts:

• Estaspray should never be applied to the breast or to skin with wounds or irritation.
• Estaspray should be kept away from reach of children.

Gardian Minimizes Risk, Maximizes protection.

 Gardian is a novel, scientifically designed combination of Methylating agents and antioxidants to protect against the pregnancy complications due to micronutrient deficiency or hyperhomocysteinaemia and free radical generation.

All the constituents of Gardian are multidimensional in their activities and very essential for the optimal functioning of normal life sustaining processes.

Composition:  

Methylating Agents	Free Radical Scavengers
Methionine             50mg	Lycopene             6mg
Choline                  10mg	Teavigo               250mg
Vitamin B6             24mg	Vitamin C            295mg
Folic Acid                750mcg	Vitamin E            19.46mg
Vitamin B12            20mcg	Selenium            50mcg

Highlights :

The Methylating Team

Methionine:
Strongly predicts final birth weight and length
It is also critical factor affecting fetal growth

Choline:
Prevents elevated Homocysteine concentations
Converts Homocysteine to Methionine

Vitamin B6:
Helps in converting Homocysteine to Cysteine

Folic Acid:
Minimizes risk of pregnancy complications and birth defects

Vitamin B12:
Helps in converting Homocysteine to Methionine
Deficiency of Vitamin B12 can lead to accumulation of Homocysteine

The Free Radical Scavenger Team

Lycopene:
Reduces the development of PIH and IUGR
Reduces Oxidative stress during pregnancy
Gardian provides optimal dose of Lycopene - 6mg/day

Teavigo
Increases the level of NO, a potent vasodilator,
which normalizes the blood pressure in PIH
Lowers LDL cholesterol

Vitamin C
Prevents pre-eclampsia in women at high risk

Vitamin E
Beneficial in PIH as it reduces blood pressure

Selenium:
Protective properties against endogenous and exogenous aggression

Indications

• History of early pregnancy loss, placental abruption and Neural tube defects.
• Pre- eclampsia
• Early cases of intra- uterine growth restriction.
• Recurrent miscarriages
• Recurrent abortion

Dose and Administration:
1 tablet daily

Sets the sperm on right track .

Deficiency of methylating agents leads to male infertility due to hyperhomocysteinaemia which reduces the testicular blood flow.

25% infertile men have high serum ROS level which correlates negatively with sperm motility.

Composition:

Tablet A  

Methylating Agents	Free Radical Scavengers
DL- methionine 50mg	Lycopene 6mg
Folic acid 750mcg,	Teavigo 250 mg
Vitamin B6 24mg,	Vitamin E 19.46mg
Vitamin B12 20 mcg	Vitamin. C 295mg
Choline 10mg	Selenium 50 ug

 Tablet B

L- Carnitine 500mg
Zinc (as Zinc oxide) 15 mg.

Highlights

• Normalizes the levels of homocysteine
• Improves testicular blood flow
• Provides energy to the sperms, increases the sperm count and sperm motility.

Indications :

• Oligo/ Astheno/ Globo/Teratozoospermia
• 2-3 months prior to intrauterine insemination and invitro fertilization

Safe adjunct to

• Support recovery of function following varicocele repair and vas-reversal procedures.
• Assures optimal sperm health throughout ART

Dosage and Administration:
Tablet A and Tablet B to be taken together once a day.

For Your Eyes Only

Oxidative stress, ageing process and nutritional deficiency are common risk factors for

• AMD
• Diabetic Retinopathy

Ocugard is a revolutionary combination of natural pigments of eye (Lutein + Zeaxanthin) and vital nutritional ingredients and free radical scavengers.

 Composition  

•  Natural Pigments Of Eye

Lutein 3mg
Zeaxanthin 0.5mg

 •  Natural Eye Cofactor For Enzyme

Zinc 12.5mg

 •  Vital Nutritional Ingredients

Ginkgo biloba extract 60mg
Rutin 25mg
Selenium 13mcg

 •  Free Radical Scavengers

Bilberry extract 5mg
Vitamin E 100 IU
Vitamin C 250mg
Beta Carotene 2.5mg
Alpha Lipoic Acid 37.5 mg

Highlights of Ocugard:

 In Age Related Macular Degeneration:
Significantly reduces the progression of AMD by 27%
Lowers the risk of AMD by 25%

Ref: ( Arch Opthalmal.2001; 119: 1417-1436)

In Diabetic Retinopathy:
Lutein and Zeaxanthin increases macular pigment density in retina.
Enhances microcirculation in the retinal capillaries
Inhibits the sorbitol accumulation

Ref: (Alt Med Rev .2001;6(5) :500-503)

Indications
As an adjunct in :-

• ARMD or AMD
• Diabetic Retinopathy

Dosage and Administration
One or two tablets at a time daily for 3 months.

Visit www.ribocor.info

 The Cardiac Energizer

D- Ribose, is a five carbon monosaccharide that is vital for the cellular synthesis of ATP (Adenosine triphosphate).
ATP is the energy currency of the cell. It provides the power all cells need for the function.
Cardiac energy metabolism plays a pivotal role in heart function.
Congestive heart failure, ischemic heart disease and cardiomyopathy deplete cardiac energy stores by 30% or more, contributing to chronically depressed heart function.
Ribose administration accelerates ATP synthesis helping to supply the crucial energy reserve needed.

Composition
D- ribose – 5gm per sachet

Highlights of Ribocor:

In Post MI cases:

• Significantly increases ATP recovery post ischemia
• Can be safely co-prescribed with other cardiovascular drugs
• Restores oxygen utilization efficiency

In Stable Coronary Artery Disease:

• 49% greater increase in cardiac indices post Coronry Artery Bypass Crafting
• Increases exercise tolerance

In CHF:

• Improves ejection fraction from 17% to near normal 60%
• Improves diastolic heart function
• Improves quality of life in heart patient.

In Fibromyalgia:

• Improves the energy recovery time in skeletal muscle
• Relieves fatigue, soreness, and stiffness after intense exercise.
• Passes GRAS test (Generally Regarded As Safe) according to US FDA

 Indications:

 As an adjunctive therapy in -

• Congestive heart failure
• Chronic ischemic heart disease
• Open – heart surgical procedure
• Post MI event
• Fibromyalgia
• Chronic fatigue

Dosage of Administration

 Sever Form of Dieseases

Advanced congestive heart failure Patients awaiting heart transplant Dilated Cardiomyopath Frequent lethargy Fibromyalgia 2-3 sachet (10-15g)daily

Moderate Form of Diseases

Congestive heart failure Ischemic Cardiomyopathy Peripheral Vascular Diesease Pateint recovering from heart surgery or heart attack Stable Angina Pectoris 1-2 sachet (5-10g)daily

As a Preventive Measure in

Cardiovascular diseases Unstable hypertension 1 sachet (5gm)daily

Neurogardian :- A team of Methylating agents and free radical scavenger with Methylcoblamin

Composition :  

Methylating Agents	Free Radical Scavengers
Methylcobalamin 1500 mcg	Lycopene 6mg
Folic acid 750 mcg	Vitamin C 300 mg
Vitamin B6 24 mg	Vitamin E 19.46 mg
methionine 50 mg	Teavigo 250mg
Choline 10 mg	Selenium 50 mcg

Highlights of Neurogardian:

• Methylcobalmin protects nerve cells against NMDA-mediated cytotoxicity induced by hyperhomocystienemia and plays an important role in rejuvenation of the nervous tissues.
• The entire team of Methylating agents helps in maintaining optimal methylation at the cellular level and keeps a check on the levels of homocysteine, which is an independent risk factor for stroke and leads to regression of carotid plaques.
• The entire team of free radical scavengers protects the brain cells against the damage done by excessive free radical generation, prevents lipid peroxidation protect against ischemic brain injury.
• Lycopene like antioxidants has shown to reduce the intimal wall thickness and risk of infarction thereby helping in reducing the incidence of stroke and other vascular abnormalities in the brain. It also reduces infarct volume in ischemic brain injury.
• Neurogardian prevents secondary stroke and stroke in high risk group.

Indications

• Prevention of secondary stroke
• Patients with high risk of stroke

  •  Patients with pre- existing atherosclerotic vascular diseases, diabetes,    hypertension.
  •  Vegans at high risk of stroke.

Dosage and Administration
One tablet Daily

3 ‘R' Approach In Neuropathic Pain

 Diabetic peripheral neuropathy is estimated to be present in 50% people with diabetes mellitus.

Post herpetic neuralgia affects about 50% of patients over 60 years of age and 15% of all herpes zoster patients.

Neuropathic pain is due to neuronal damage, increased glutamate release and increased oxidative stress

In all cases of Neuropathic pain treatment goal is to

• Relieve pain
• Revive neuron
• Rejuvenate neuron

Composition:

• Gabapentin – 300mg
• Methylcobalamin – 500mcg
• Alpha Lipoic Acid -100mg

Highlights of Gabamet:

Gabapentin – Reduces hyperalgesia and allodynia

• Increases levels of GABA by inhibiting GABA aminotransferase
• Blocks a 2 d subunits of voltage dependent calcium channels.
• Blocks NMDA receptor and glutamate release.

Methylcobalamin – Enhances Motor and sensory functions of neurons

• Improves axonal regeneration
• Increases myelination of neurons by stimulating lecithin synthesis
• Protects nerve cells from glutamate
• Improves nerve function.

Alpha Lipoic Acid – Rapidly and significantly reduces sensory symptom and pain

• Dual antioxidant protection – stronger defense against damaging free radicals
• Protects nerves from oxidative damage and inflammation
• Improves microcirculation system for carrying oxygen to nerve cells
• Increases ATP production
• Improves quality of life.

Indications:
Diabetic Peripheral Neuropathy
Post Herpetic Neuralgia
Post Traumatic Neuralgia
Trigeminal Neuralgia
Low Back Pain

Dosage and Administration:
Initiate therapy with 1tab at bed time.
Dose can be titrated to 1-2 tab. thrice daily as tolerated and as needed for maximum pain relief.
Gabamet dose if altered then should be done gradually over minimum 1 week period.

Herpes zoster is an acute cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV), a herpes virus that initially causes chickenpox. After resolution of the primary VZV (chickenpox) infection, the virus lies dormant in the dorsal root ganglion until it undergoes local dermatomal reactivation in the form of herpes zoster.

Genital herpes (GH) is a recurrent sexually transmitted infection ( STI ) that causes significant morbidity and is also the major source of herpes simplex virus (HSV) infection in cases of neonatal herpes. Genital herpes increases the transmission of HIV infection.

Cipla Protec introduces for the first time in India , Valcivir, Valacyclovir 500 and 1000mg tablets.

As per Reputed international journal DRUGS “Low oral bioavailability of acyclovir has to some extent limited its efficacy in the treatment of herpes zoster and has prompted the development of more readily absorbed oral prodrug, valacyclovir.”

Composition:
Each Valcivir 500 tablet contains Valacyclovir hydrochloride 500mg
Each Valcivir 1000 tablet contains Valacyclovir hydrochloride 1000mg

Highlights of Valcivir:
Higher oral bioavailability (70%) as compared to acyclovir (20%)



Effective even 72 hrs.after onset of rash



Faster relief in zoster associated pain



Superior efficacy in reducing Post – herpetic neuralgia (PHN) as compared to acyclovir.



After 6 months 81% patients free of pain



Faster relief of abnormal sensation



• Only Oral medication for treatment of H. Labialis
• Only drug approved for reduction in transmission for a source partner.
• Only drug approved for HIV + patients suffering from HSV.
• Dosage convenience.
• Well tolerated- safe for long term use

 Indications:

• Herpes Zoster
• Genital Herpes

  -Initial episodes
  -Recurrent episodes
  - Suppressive therapy
  -Suppressive therapy for patients with HIV infection

• Herpes Labialis
• CMV infection
• Chickenpox in Children
• Herpes zoster Ophthalmicus

Dosage and Administration:

Extended Coverage

• Ofloxacin in combination with Nitazoxanide .
• Ofloxacin is a broad - spectrum fluroquinolon

Nitazoxanide is a synthetic anti-parasitic agent which inhibits the energy metabolism in anaerobic bacteria causing death of anaerobic bacteria.

It is different from other anti–parasitic agents in its wide spectrum of activity, efficacy and safety

•  Ofloxacin is superior to ciprofloxacin and norfloxacin with higher bioavailability.

Composition
Ofloxacin – 200mg
Nitazoxanide – 500mg

Highlights:

• Oflox – N wider coverage in mixed infections.
• Free from metallic taste unlike Nitroimidazoles.
• BID dosage convenience.
• Leads to resolution of symptoms within 1.5 days in diarrhea.
• Successful in the treatment of metronidazole resistance giardiasis.
• Provides complete resolution of diarrheal symptoms.

Indications  

•  Diarrhoea

•  Acute Diarrhoea
•  Watery Diarrhoea
•  Bloody Diarrhoea
•  Nosocomial Diarrhoea
•  Traveller's Diarrhoea
•  Viral Diarrhoea

•  Gastroenteritis
•  Gynecological infections
•  ENT Infections
•  Orodental Infections

Dose & administration
1 Tab BID for 3-5 days