As long as we are alive, eating and breathing in a polluted world, our bodies will have to contend with free radicals and we will need antioxidants to help reduce the impact and minimize the damage they cause. Normally, the body can handle free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. Of particular importance is that free radical damage accumulates with age.

As we get older our eyes have a harder time fighting off free radicals that cause oxidative stress damage. Aging process brings about anatomical changes in the eye, which results in physiological changes simultaneously.

Ocugard is a comprehensive blend of essential carotenoids, free radicascavengers, multivitamins and other vital ingredients designed for protection of eyes against age related macular degeneration (AMD), cataract, glaucoma and diabetic retinopathy. Ocugard thus plays an important role in preventing the damage to the human eye due to destructive action of free radicals as it contains antioxidants.

Ocugard plays an important role in preventing the damage to the human eye due to destructive action of free radicals as it vital ocular antioxidants like rutin , alpha-lipoic acid , ginkgo biloba extracts , bilberry extracts , lutein , zeaxanthin , zinc ,selenium , vitamin C , vitamin E and beta-carotene .

Indications

• Ocugard can be given as an adjunct in patients with age related macular degeneration.
• Patients sufferings / at high risk from cataract.
• Patients suffering / at high risk from glaucoma.
• Postoperative patients of cataract or glaucoma.
• Diabetic patients as a prophylaxis against cataract.
• Patients with idiopathic raised intraocular pressure, and in patients with diabetic retinopathy.

What is the recommended dosage of Ocugard?
The recommended dosage of Ocugard is two tablets at a time daily or as recommended by the doctor.

Warnings
Current and Former Smokers: Consult your eye care professional about the risks associated with smoking and using beta-carotene.

Ocular allergy occurs in approximately 15%-20% of the general population. Seasonal allergic conjunctivitis (SAC) is the most common form of this disease. Transient ocular itching and hyperemia, the primary signs and symptoms of SAC, are manifested typically during the spring, summer.

IF1 contains olopatadine 0.2%, which is a long-acting multiple-action topical agent with mast cell stabilizing and antihistaminic properties.

Olopatadine is the first dual-action agent approved by the US FDA combining antihistaminic properties with mast-cell stabilizing activity, thus creating an eye-drop with strong immediate efficacy as well as long-lasting therapy.

Olopatadine is a relatively selective histamine H1 antagonist and an inhibitor of the release of histamine from the mast cells. Decreased chemotaxis and inhibition of eosinophil activation has also been demonstrated. Olopatadine decreases adhesion molecule expression results in decreased leukocyte infiltration and prevention of other events which lead to inflammatory process associated with allergy

Olopatadine is devoid of effects on alpha-adrenergic, dopaminergic, and muscarinic type 1 and 2 receptors.

Indications
Olopatadine hydrochloride 0.2% ophthalmic solution is indicated for the treatment of ocular itching associated with allergic conjunctivitis.

Dosage and Administration
The recommended dose of olopatadine 0.2% is one drop in each affected eye once a day

IF1 Highlights

(1)Potent anti-histaminic ability and mast cell stabilizing activity

• Olopatadine 0.2% has also demonstrated its ability to act as a potent antihistamine, on a level superior to other selective H1 antihistamines
• Olopatadine is the first topical ophthalmic anti-allergy agent that has clinically shown mast-cell stabilization in human eyes.

 (2) Fast Acting
Reduces itching symptoms within 3 minutes of administration to the eyes

 (3) Long lasting relief
Dual mechanism of action gives an immediate and a long lasting relief for upto 24 hrs

 (4) Comparison with other dual acting agents

• Olopatadine has been shown to inhibit 96% of histamine release from human conjunctival mast cells in vitro , even at 10 times the clinically maximally effective dose.
• On the other hand, results for other dual acting agents revealed a biphasic response, whereby low concentrations suppressed histamine release, but as the concentration was increased, histamine release was actually stimulated.

(5) Soothes the eyes

• Olopatadine 0.2% formulation contains povidone, which makes it soothing and well tolerated on the ocular surface.
• Olopatadine 0.2% can be used in allergic conjunctivitis patients with mild to moderate dry eye also.

 (6) Convenient dosing

• Simple once a day dosing – helps in increasing patient compliance
• Safe and well tolerated, improves quality of life of patients with allergic conjunctivitis.

Epinastine 0.05%
Ocular allergy occurs in approximately 15%-20% of the general population. Seasonal allergic conjunctivitis (SAC) is the most common form of this disease. Transient ocular itching and hyperemia, the primary signs and symptoms of SAC, are manifested typically during the spring, summer.

Epinastine ophthalmic solution 0.05% is a clear, colorless, sterile isotonic solution containing epinastine HCl, an antihistamine and an inhibitor of histamine release from the mast cell for topical administration to the eyes.

Epinastine is a topically active, direct H 1 -receptor antagonist and an inhibitor of the release of histamine from the mast cell. Epinastine is selective for the histamine
H 1 -receptor and has affinity for the histamine H 2 -receptor. Epinastine also possesses affinity for the a 1 -, a 2 -, and 5-HT 2 -receptors. Epinastine does not penetrate the blood/brain barrier and, therefore, is not expected to induce side effects of the central nervous system.

Indications
Epina eye drops are indicated for the prevention of itching associated with allergic conjunctivitis

 Dosage and Method of Administration
The recommended dosage is one drop in each eye twice a day.

Treatment should be continued throughout the period of exposure (i.e., until the pollen season is over or until exposure to the offending allergen is terminated), even when symptoms are absent.

EPINA Highlights

Mechanism of Action  
•  Multi-action control of signs and symptoms
•  Affinity for both H1 and H2 receptors ,thus providing relief from

•  Ocular itch
•  Vasodilatation , eye lid swelling , redness , facial edema
•  Mast cell stabilizing action

•  100-200 times higher affinity for H1 receptors as compared to histamine
•  Non-sedating antihistaminic action

Onset and Duration of Action
•  Fast acting: Onset of action within 3 mins .
•  Long Lasting sustained relief for more than 12 hours

Soothing For Ocular Surface
•  Soothing effect: Comfortable on the ocular surface
•  Does not exacerbate ocular surface drying.

Compliance, Comfort and Tolerability
•  Simple BID dosing :May increase compliance
•  Safe and effective for up to 8 weeks, without evidence of tachyphylaxis

As long as we are alive, eating and breathing in a polluted world, our bodies will have to contend with free radicals and we will need antioxidants to help reduce the impact and minimize the damage they cause. Normally, the body can handle free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. Of particular importance is that free radical damage accumulates with age.

As we get older our eyes have a harder time fighting off free radicals that cause oxidative stress damage. Aging process brings about anatomical changes in the eye, which results in physiological changes simultaneously.

Fiteye contains Vitamin C, Vitamin E, Vitamin A, Vitamin B 2 , Zinc, Copper, Selenium , Manganese , L-Glutathione , Lutein , Zeaxanthin and Rutin .

Fiteye plays an important role in preventing the damage to the human eye due to destructive action of free radicals as it contains antioxidants

Who should take Fiteye?

Fiteye is formulated to provide nutritional and antioxidant support for the eye and is recommended for patients who are not taking a multi-vitamin supplement. Fiteye is recommended for all people over 50 years of age as a valuable part of daily eye health care regimen.

Fiteye is particularly beneficial to those exposed to environmental pollution or stress, which increases the risk of damage by free radicals, those who suffer from diabetes, cardiovascular disorders, cataracts, age related macular degeneration etc.

Dosage
The recommended dosage of Fiteye is one tablet one or two times daily , or as recommended by the physician

Warnings
Current and Former Smokers: Consult your eye care professional about the risks associated with smoking and using Beta-Carotene.

Fluometholone 0.1%
Steroidal eye ointments are preferred in certain conditions like blepharitis, keratitis, scleritis, episcleritis, post external and internal ocular surgeries, post refractive surgeries and ocular injuries.

Clinical Efficacy

• Post (ALT) fluorometholone decreases ocular inflammation and discomfort during the early post-operative period.
• Post PRK fluorometholone reduces postoperative inflammatory response, and decreases the stromal reparative response.

Flomex Eye ointment enables

• Maximum contact time of the fluorometholone
• Increases the bioavailability of the same,
• Maintains consistent dosage of the drug.

Safety Profile

• Lower propensity to raise IOP
• Safe for Glaucoma Patients
• Safe for long term use
• Safe for steroid responders
• Safe for elderly people
• Safe for children over 2 years of age

Indications
Fluorometholone ophthalmic ointment is indicated for the treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.

Dosage
A small amount (approximately 1 / 2 inch ribbon) of ointment should be applied to the conjunctival sac one to three times daily. During the initial 24 to 48 hours, the frequency of dosing may be increased to one application every four hours.

The dosing of fluorometholone ophthalmic ointment may be reduced, but care should be taken not to discontinue therapy prematurely. In chronic conditions, withdrawal of treatment should be carried out by gradually decreasing the frequency of applications.

Moxifloxacin 0.5% Eye Ointment
Moxifloxacin available in India for the first time as an eye ointment, with the advantage of being preservative free.
Moxifloxacin is a 8-methoxy fluoroquinolone anti infective. Moxicip eye ointment is a semisolid preparation in which the active drug moxifloxacin is dissolved in required quantity.

Antimicrobial Spectrum

• Moxifloxacin is a broad spectrum antibiotic
• Moxifloxacin possesses enhanced activity against gram-positive organisms while maintaining its efficacy against the gram-negative organisms.
• Strengthened potential against gram-positive cocci like Staphylococcus aureus , Streptococcus pneumoniae.
• Hinders resistance.
• 8 to 16 times more potent against gram-positive organisms than previous generation quinolones . Demonstrates susceptibility for isolates that are second and third generation fluoroquinolone resistant.

Clinical Efficacy
Moxifloxacin cures more than 80% of neonates with bacterial conjunctivitis Moxicip Eye ointment enables:

• Maximum contact time of the moxifloxacin
• Increases the bioavailability of the same,
• Maintains consistent dosage of the drug.

 Indications

• Moxifloxacin eye ointment is indicated for treatment of external bacterial infections of the eyes like conjunctivitis, meibomianitis, chalazion, stye, blepheritis.
• It is an ideal agent for empiric treatment of superficial ocular infections and ocular infections requiring prolonged contact time of the drug.
• Treatment of conjunctivitis in neonates and pediatrics.
• Treatment of bacterial keratitis.
• Efficacious for postoperative ocular pad dressings and night time use.

Dosage
Apply half-inch ribbon three times a day on the first two days. For the next five days apply half-inch ribbon two times a day.

Highlights

• World's first preservative free moxifloxacin eye ointment
• Preservative free
• Can be used in pediatrics

Adlube is an ocular lubricant containing white petrolatum (57.5%) and mineral oil (42.5%).

Highlights
It is the FIRST STERILE PRESERVATIVE FREE ocular lubricating ointment available in India.  It is one of the BEST ocular lubricant combinations. It has no preservative and hence, gentle enough to be used as often as needed without damaging the eye vision. It is safe and effective for dry eye. It is thicker and greasier and hence, stays in eye for a much longer time than eye drops. It provides long lasting relief for dry eye. It prevents abrasion at night and reduces need for artificial tears and warm compressors. It has provided a new therapeutic approach to provide steady levels of medication to ocular surface. It also prevents brittleness and / or breaking of eyelashes.

 Indications
For the temporary relief of burning, irritation and discomfort due to dryness of the eye or due to exposure to wind or sun. Also may be used as a protectant against further irritation.

Dosage and Method of Administration
For topical ocular administration.

Wash your hands before use. Pull down the lower lid of the affected eye and apply a small amount (one fourth inch) of ointment to the inside of the eyelid. (Ideal for use at bedtime). There is no variation in dosage for age. To avoid contamination, do not touch tip of the container to any surface. Replace cap after using.

Brimocom (Brimonidine-timolol) consists of two active substances: brimonidine tartrate and timolol maleate. These two components decrease elevated intraocular pressure (IOP) by complementary mechanisms of action and the combined effect results in additional IOP reduction compared to either compound administered alone. Brimocom has a rapid onset of action.
Highlights

1. Brimocom contains 2 well trusted established medications in glaucoma therapy i.e Timolol, which is well-established gold standard beta-blocker in glaucoma treatment and brimonidine is well tolerated by patients and has favorable ocular and systemic safety profile
2. Brimocom has dual mechanism of action i.e it increases outflow as well as decreases production of aqueous humor.
3. Brimonidine-timolol fixed combination produces a statistically significant greater lowering of IOP as compared to either Timolol or Brimonidine monotherapy.
4. Brimonidine-timolol fixed combination reduced IOP by up to 33% (7.6 mm Hg) from an untreated baseline of 23.3mmHg.
5. Brimocom contains Brimonidine, which confers the added advantage of Neuroprotection
6. Brimocom is dosed twice daily , which offers  BD convenience,

Indications
Brimonidine-timolol fixed combination is indicated for reduction of intraocular pressure (IOP) in patients with chronic open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta-blockers

Dosage and Method of Administration
The recommended dose in adults is one drop of Brimocom in the affected eye(s) twice daily, approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.