Each tablet contains
Ritonavir ……..100 mg

RITOMUNE is indicated in combination with other antiretroviral agents for the treatment of HIV-infection.

It is recommended that RITOMUNE be taken with meals if possible. RITOMUNE is administered orally.

Adults
Recommended dosage: The recommended dosage of ritonavir is 600 mg twice daily by mouth. Use of a dose titration schedule may help to reduce treatment-emergent adverse events while maintaining appropriate ritonavir plasma levels. Ritonavir should be started at no less than 300 mg twice daily and increased at 2 to 3 day intervals by 100 mg twice daily.

General Dosing Guidelines
Patients should be aware that frequently observed adverse events, such as mild to moderate gastrointestinal disturbances and paresthesias, may diminish as therapy is continued. In addition, patients initiating combination regimens with RITOMUNE and reverse transcriptase inhibitors may improve gastrointestinal tolerance by initiating RITOMUNE alone and subsequently adding reverse transcriptase inhibitors before completing two weeks of RITOMUNE monotherapy.

RITOMUNE is contraindicated in patients with known hypersensitivity to ritonavir or any of its ingredients.

Co-administration of RITOMUNE is contraindicated with the drugs listed in Table 3 (also see WARNINGS AND PRECAUTIONS – Table2. Drugs that Should Not be Co-administered with RITOMUNE because competition, for primarily CYP3A, by ritonavir could result in inhibition of the metabolism of these drugs and create the potential for serious and/or life-threatening reactions such as cardiac arrhythmias, prolonged or increased sedation, and respiratory depression. Voriconazole is an exception in that co-administration of RITOMUNE and Voriconazole results in a significant decrease in plasma concentrations of Voriconazole.

Table 2: Drugs that are Contraindicated with Ritonavir Use