Adults
The recommended dose of EFAVIR Capsules and Tablets is 600 mg orally, once daily, in combination with a protease inhibitor and/or nucleoside reverse transcriptase inhibitors (NRTIs).
It is recommended that EFAVIR Capsules and Tablets be taken on an empty stomach, preferably at bedtime. The increased efavirenz concentrations observed following administration of EFAVIR Capsules and Tablets with food might lead to an increase in the frequency of adverse events (see PHARMACOLOGY, Pharmacokinetics, Effect of Food on Oral Absorption ). Dosing at bedtime may improve the tolerability of nervous system symptoms (see WARNINGS AND PRECAUTIONS, Nervous System Symptoms and UNDESIRABLE EFFECTS ).
Concomitant Antiretroviral Therapy
EFAVIR Capsules and Tablets must be given in combination with other antiretroviral medications (see WARNINGS AND PRECAUTIONS, Drug Interactions and INDICATIONS ).
Dosage Adjustment
If EFAVIR Capsules and Tablets are co-administered with voriconazole, the voriconazole maintenance dose should be increased to 400 mg every 12 hours and the efavirenz dose should be decreased to 300 mg once daily, using the EFAVIR Capsules formulation (three 100 mg capsules or one 200 mg and one 100 mg capsule).
Pediatric Patients
It is recommended that EFAVIR Capsules and Tablets be taken on an empty stomach, preferably at bedtime. Table 1 describes the recommended dose of EFAVIR Capsules and Tablets for pediatric patients, 3 years of age or older and weighing between 10 and 40 kg. The recommended dose of efavirenz for pediatric patients weighing greater than 40 kg is 600 mg once daily.
Table 1: Pediatric Dose to be Administered Once Daily
Body Weight |
Efavirenz
Dose (mg) |
kg |
lbs |
10 to <15 |
22 to <33 |
200 |
15 to <20 |
33 to <44 |
250 |
20 to <25 |
44 to <55 |
300 |
25 to <32.5 |
55 to <71.5 |
350 |
32.5 to <40 |
71.5 to <88 |
400 |
at least 40 |
at least 88 |
600 |
|
