The recommended dosage of indinavir is 800 mg (two 400 mg capsules) orally every 8 hours.
For optimal absorption, indinavir should be administered without food but with water 1 hour before or 2 hours after a meal. To ensure adequate hydration, it is recommended that the patient drink at least 1.5 litres (approximately 48 ounces) of liquids during the course of 24 hours.
Concomitant therapy
Delavirdine
Dose reduction of indinavir to 600 mg every 8 hours should be considered when administering delavirdine 400 mg three times a day.
Didanosine
If indinavir and didanosine are administered concomitantly, they should be administered at least one hour apart on an empty stomach.
Itraconazole
Dose reduction of indinavir to 600 mg every 8 hours is recommended when administering itraconazole 200 mg twice daily concurrently.
Ketoconazole
Dose reduction of indinavir to 600 mg every 8 hours is recommended when administering ketoconazole concurrently.
Rifabutin
Dose reduction of rifabutin to half the standard dose and a dose increase of indinavir to 1000 mg (three 333-mg capsules) every 8 hours are recommended when rifabutin and indinavir are coadministered.
Hepatic Insufficiency
The dosage of indinavir should be reduced to 600 mg every 8 hours in patients with mild-to-moderate hepatic insufficiency due to cirrhosis.
Nephrolithiasis/Urolithiasis
In addition to adequate hydration, medical management in patients who experience nephrolithiasis/urolithiasis may include temporary interruption (e.g. 1-3 days) or discontinuation of therapy.
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