Adults : The recommended dose is 1250 mg (five 250 mg tablets) twice daily or 750 mg (three 250 mg tablets) three times daily. NELVIR should be taken with a meal. Patients unable to swallow the 250 or 625 mg tablets may dissolve the tablets in a small amount of water. Once dissolved, patients should mix the cloudy liquid well, and consume it immediately. The glass should be rinsed with water and the rinse swallowed to ensure the entire dose is consumed.
Pediatrics Patients(2-13 years) : In children 2 years of age and older, the recommended oral dose of NELVIR 250 mg tablet is 45 to 55 mg/kg twice daily or 25 to 30 mg/kg three times daily. All doses should be taken with a meal. Doses higher than the adult maximum dose of 2500 mg per day have not been studied in children.
Tables 6 provide dosing guidelines for NELVIR tablets based on age and body weight.
Table 6: Dosing for Children ≥ 2 Years of Age (Tablets)
Body Weight |
Twice Daily (BID) 45-55 mg/kg ≥ 2 years |
Three Times Daily (TID) 25-35 mg/kg ≥2 years |
Kg. |
Lbs. |
# of tablets
(250 mg) |
# of tablets
(250 mg) |
10 - 12 |
22 –26.4 |
2 |
1 |
13 – 18 |
28.6 – 39.6 |
3 |
2 |
19 – 20 |
41.8 – 44 |
4 |
2 |
≥21 |
≥ 46.2 |
4 – 5 1 |
3 2 |
1 For BID dosing, the maximum dose per day is 5 tablets BID
2 For TID dosing, the maximum dose per day is 3 tablets TID |
Hepatic Impairment: NELVIR can be used in patients with mild hepatic impairment without any dose adjustment. NELVIR should not be used in patients with either moderate or severe hepatic impairment (see PHARMACOLOGY : Special Populations). |
